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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TXNRD2
All Species:
38.18
Human Site:
S74
Identified Species:
56
UniProt:
Q9NNW7
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NNW7
NP_006431.2
524
56507
S74
V
V
D
Y
V
E
P
S
P
Q
G
T
R
W
G
Chimpanzee
Pan troglodytes
XP_001166615
481
51948
V67
L
G
R
K
V
A
V
V
D
Y
V
E
P
S
P
Rhesus Macaque
Macaca mulatta
NP_001152971
524
56314
S74
V
V
D
Y
V
E
P
S
P
Q
G
T
R
W
G
Dog
Lupus familis
XP_850181
509
55065
S61
V
V
D
Y
V
E
P
S
P
R
G
T
K
W
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9JLT4
524
56434
S74
V
A
D
Y
V
E
P
S
P
R
G
T
K
W
G
Rat
Rattus norvegicus
Q9Z0J5
526
56406
S76
V
A
D
Y
V
E
P
S
P
R
G
T
K
W
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001116163
518
56137
S64
V
L
D
Y
V
E
P
S
P
R
G
T
K
W
G
Frog
Xenopus laevis
NP_001080052
504
54666
S54
V
F
D
Y
V
E
P
S
P
R
G
T
K
W
G
Zebra Danio
Brachydanio rerio
NP_898895
602
65949
T150
V
L
D
Y
V
V
P
T
P
Q
G
T
A
W
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P91938
596
64304
P150
L
D
F
V
K
P
T
P
T
L
G
T
K
W
G
Honey Bee
Apis mellifera
NP_001171496
537
59227
S88
V
L
D
F
V
T
P
S
P
R
G
S
T
W
G
Nematode Worm
Caenorhab. elegans
Q17745
667
74094
S207
C
L
D
F
V
K
P
S
P
Q
G
T
S
W
G
Sea Urchin
Strong. purpuratus
XP_797733
490
53044
G52
S
P
Q
G
T
K
W
G
L
G
G
T
C
V
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P48641
499
53852
I61
C
E
L
P
F
H
P
I
S
S
E
E
I
G
G
Baker's Yeast
Sacchar. cerevisiae
P41921
483
53422
A56
T
L
L
V
E
A
K
A
L
G
G
T
C
V
N
Red Bread Mold
Neurospora crassa
Q873E8
468
50294
V52
T
C
V
N
V
G
C
V
P
K
K
V
T
F
Y
Conservation
Percent
Protein Identity:
100
91
98.2
83.2
N.A.
84.5
82.6
N.A.
N.A.
72.9
68.6
47
N.A.
48.9
53
40.7
55.7
Protein Similarity:
100
91.2
99
91.4
N.A.
91.5
90.8
N.A.
N.A.
86
82.2
62.2
N.A.
62.4
68.5
56.2
69.8
P-Site Identity:
100
6.6
100
86.6
N.A.
80
80
N.A.
N.A.
80
80
73.3
N.A.
26.6
60
66.6
13.3
P-Site Similarity:
100
13.3
100
100
N.A.
93.3
93.3
N.A.
N.A.
100
93.3
86.6
N.A.
40
86.6
86.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.7
32.8
34.7
Protein Similarity:
N.A.
N.A.
N.A.
51.7
53
52.4
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
26.6
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
0
0
0
13
0
7
0
0
0
0
7
0
0
% A
% Cys:
13
7
0
0
0
0
7
0
0
0
0
0
13
0
0
% C
% Asp:
0
7
63
0
0
0
0
0
7
0
0
0
0
0
0
% D
% Glu:
0
7
0
0
7
44
0
0
0
0
7
13
0
0
0
% E
% Phe:
0
7
7
13
7
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
0
7
0
7
0
7
0
7
0
13
82
0
0
7
75
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
0
% I
% Lys:
0
0
0
7
7
13
7
0
0
7
7
0
38
0
0
% K
% Leu:
13
32
13
0
0
0
0
0
13
7
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
13
% N
% Pro:
0
7
0
7
0
7
69
7
69
0
0
0
7
0
7
% P
% Gln:
0
0
7
0
0
0
0
0
0
25
0
0
0
0
0
% Q
% Arg:
0
0
7
0
0
0
0
0
0
38
0
0
13
0
0
% R
% Ser:
7
0
0
0
0
0
0
57
7
7
0
7
7
7
0
% S
% Thr:
13
0
0
0
7
7
7
7
7
0
0
75
13
0
0
% T
% Val:
57
19
7
13
75
7
7
13
0
0
7
7
0
13
0
% V
% Trp:
0
0
0
0
0
0
7
0
0
0
0
0
0
69
0
% W
% Tyr:
0
0
0
50
0
0
0
0
0
7
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _